Pii: S0149-7634(97)00029-8

SALANSKY, N., A. FEDOTCHEV AND A. BONDAR. Responses of the nervous system to low frequency stimulation and EEG rhythms: clinical implications. NEUROSCI BIOBEHAV REV 22(3) 395–409, 1998.—The present paper reviews literature data on the role of the non-specific central nervous system response mechanisms on the therapeutic effects of relatively weak external stimulations used in clinical practice. The factors affecting the stimulation efficiency and increased sensitiveness of living things to extra-lowfrequency periodic stimulations (in the range of from less than 1 Hz to tens of Hz) are discussed. Among the factors determining such effects, the non-specific response mechanisms of the nervous system, the resonance phenomena in different organism systems, and the interaction of external stimulation with endogenous rhythmic processes are analyzed. Most attention is given to endogenous rhythms of the electrical brain activity reflected in the EEG rhythms. A high resolution EEG processing approach that is used to reveal the intrinsic oscillators in the individual EEG spectrum is described. Synchronization of sensory stimulation parameters with the frequencies of intrinsic EEG oscillators is supposed to be an appropriate way to enhance the therapeutic effects of various sensory stimulation treatments. Specific methods for utilizing resonance therapy via sensory stimulation with intrinsic EEG frequencies, and for automatic modulation of stimulation parameters by endogenous organism rhythms are delineated; some preliminary results are described. q 1998 Published by Elsevier Science Ltd. All rights reserved.